INS and major depressive disorder: In model 1 of the multinomial regression using the PHQ-9 as a continuous variable, there was a significant effect of depression symptoms on glycaemic control (B = 0.03, p = 0.039), after adjusting for variables which had a significant association with PHQ-9 as potential confounders (namely, gender, BMI, prescribed insulin, having past history of depression and hypertension, and not following any physical activity programme (see Table 2).