In the overall study population including screen-detected diabetes, prediabetes, and normoglycemia, IR prevalence significantly decreased between 2008/09 and 2014/2016, fasting insulin from 24.8% in 2008/2009 to 16.9% in 2014/2016, HOMA-IR from 24.8% to15.4%, QUICKI from 23.6% to 13.3%, McAuley from 25.5% to 21.3%, and Matsuda from 25.5% to 18.8% (p ≤ 0.021). The gene discussed is INS; the disease is diabetes mellitus.