CXCL8 and colorectal carcinoma: In conclusion, our study identified eight hub genes, i.e. CXCL3, CXCL8, CEACAM7, CNTN3, SLC1A1, SLC16A9, SLC4A4, and TIMP1 by bioinformatics analysis, which have clinical diagnostic value for UC, CRA, and CRC.