In conclusion, our study identified eight hub genes, i.e. CXCL3, CXCL8, CEACAM7, CNTN3, SLC1A1, SLC16A9, SLC4A4, and TIMP1 by bioinformatics analysis, which have clinical diagnostic value for UC, CRA, and CRC. The gene discussed is TIMP1; the disease is colorectal carcinoma.