In conclusion, our study identified eight hub genes, i.e. CXCL3, CXCL8, CEACAM7, CNTN3, SLC1A1, SLC16A9, SLC4A4, and TIMP1 by bioinformatics analysis, which have clinical diagnostic value for UC, CRA, and CRC. This evidence concerns the gene CXCL3 and colorectal carcinoma.