Day 4: ﻿she was transferred to hospital for intubation for hypoxemic respiratory failure. PaO2/FiO2 ratio improved to 130s in prone position. After 4 days of intubation and 12 hours post-tPA, PaO2/FiO2 ratio improved to 150s (prone), but 38 hours post-tPA, the ratio was 135 in supine position (was 90 pre-tPA). The gene discussed is PLAT; the disease is respiratory failure.