When EPCs from patients with hypertension were treated in vitro with 1 μmol/L, 10 μmol/L, or 50 μmol/L aliskiren for 12 hours, the phospho-Tie2, phospho-Akt, and phospho-eNOS were enhanced in a dose-dependent manner. The gene discussed is AKT1; the disease is hypertensive disorder.