Accordingly, we hypothesized that Tie2, one of the upstream signalling mediators of the PI3K/Akt/eNOS pathway, might be activated by aliskiren and might subsequently regulate the PI3K/Akt/eNOS pathway, thus leading to an increase in the in vitro function and in vivo reendothelialization capability of EPCs in patients with hypertension. This evidence concerns the gene TEK and Hypertension.