INSR and neoplasm: According to our data these less expressed miRNAs have tumor suppressor function in many tumor types25,32,33 and mainly participate to biological pathways involved in apoptosis, in the downregulation of ERBB2 signaling, of MAP kinase activation, transmembrane receptors that regulate cell migration, the degradation of GLI2/3 transcription factors, insulin receptor signaling and WNT signaling.