As seen in subpatent primary P. falciparum infection (Figure 2b), IPA‐predicted activated upstream regulators included IFN‐γ‐related gene products, including IFNG and STAT1 in children (Supplementary figure 4b); in adults, IL‐4, IL‐6, the corresponding signal transducers STAT6 and STAT3, and triggering receptor expressed on myeloid cells‐1 (TREM1) (Supplementary figure 5b), a pathway activated in subpatent primary infection (Figure 2a). Here, IL4 is linked to infection.