The universally acknowledged prognostic factors in GBM patients comprised the age, Karnofsky Performance Status (KPS), neurologic function status, the extent of surgery, the methylation status of O6-methylguanine-DNA methyltransferase (MGMT), isocitrate dehydrogenase-1 (IDH-1) and IDH-2 status, and administration of EORTC-NCIC protocol [2, 3]. Here, IDH2 is linked to glioblastoma.