IL18 and liver dysplastic nodule: The nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is another cause of renal inflammatory injury in DN, and it converts the proinflammatory cytokines, interleukin- (IL-) 1β and IL-18, to their active forms in renal cells [8, 9].