In summary, the ruthenium-phloretin complex is accountable for the p53 intervene apoptosis in the colon carcinoma, instigated by instigation of the intrinsic apoptotic trail facilitated by the Bcl-2 and Bax and at the same time downregulating the Akt/mTOR with NF-κB/MMP-9-regulated inflammatory pathways. This evidence concerns the gene TP53 and colon carcinoma.