Melatonin reverses tunicamycin-induced ER stress by preventing the PI3K/AKT pathway, and it promotes cytotoxic response to DOX via enhancing C/EBP-homologous protein (CHOP) as well as decreasing surviving in human hepatocellular carcinoma cells [192, 193]. The gene discussed is DDIT3; the disease is hepatocellular carcinoma.