Melatonin inactivated mitophagy via blocking c-Jun-N-terminal kinases (JNK)/Parkin, resulting in the suppression of antiapoptotic mitophagy, indicating that melatonin enhances human cervical cancer HeLa cell apoptosis induced by cisplatin through inhibiting the JNK/Parkin/mitophagy axis [161, 164]. This evidence concerns the gene PRKN and cervical cancer.