Specifically, the antioxidant function is because intracellular gelsolin has five free thiol groups (cysteinyl groups) that can engage in the oxidation/reduction reaction, meanwhile its antiamyloidogenic properties were demonstrated when gelsolin inhibited the fibril formation of the β-pleated sheet structure and fibril formation of amyloid β (Aβ) peptides in an animal model of Alzheimer's disease (AD) [33]. Here, GSN is linked to Alzheimer disease.