In order to explore the underlying mechanism of the gene pair PRR11 and SKA2 on ESCC progression, the protein expression of p-AKT, total AKT, Snial and N-cadherin of EMT, and Cyclin D1 of cell cycle signal in EC9706 and EC109 cells by western blotting. Here, SKA2 is linked to esophageal squamous cell carcinoma.