This includes patients completing neoadjuvant treatment, those with clinical stage T2 or N1 oestrogen receptor (ER) positive / progestrone receptor (PR) positive / human epidermal growth factor 2 (HER2)-negative tumours, patients with triple negative or HER2-positive tumours, discordant biopsies that are likely to be malignant, and removal of a recurrent lesion [10]. The gene discussed is ERBB2; the disease is neoplasm.