Compared with free curcumin, GAMCLCL exhibited much better effects in improving the parameters of WBC, RBC, ALT, CRE, and LDH, inhibiting tumor growth, inducing apoptosis of tumor tissue, reducing MVD, downregulating the expression of VEGF-protein and mRNA, and upregulating the expression of caspase-3 protein and mRNA in H22 tumor tissues. This evidence concerns the gene VEGFA and neoplasm.