Although this study did not report whether Ang-1 and Ang-2 could be used to predict which of the children with uncomplicated malaria is slowly progressing to severe malaria, the results obtained, however, evidently demonstrated that reduced Ang-1 and increased Ang-2 levels are sensitive and specific signs of severe malaria disease that effectively differentiate between uncomplicated malaria and severe malaria. The gene discussed is ANGPT2; the disease is malaria.