ANGPT2 and malaria: This study showed that subjects with severe malaria had a significant increase of Ang-2 and Ang-2 : Ang-1 ratio but presented with a significant decrease level of Ang-1, RBC, and platelets compared with uncomplicated malaria and control subjects who had higher levels of Ang-1, RBC, and platelets and lower levels of Ang-2 and Ang-2 : Ang-1 ratio.