ACTA1 and pemphigus foliaceus: Besides the direct effects of CKD, such as body weight loss, systemic hypertension, and increased BUN, the animals of the CKD+PF group exhibited marked PM thickening, characterized by the submesothelial accumulation of collagen and α-SMA, along with peritoneal inflammation, evidenced by submesothelial macrophage and T-cell infiltration, which was statistically higher than that observed in the animals submitted only to the PF model, with no associated CKD.