Besides the direct effects of CKD, such as body weight loss, systemic hypertension, and increased BUN, the animals of the CKD+PF group exhibited marked PM thickening, characterized by the submesothelial accumulation of collagen and α-SMA, along with peritoneal inflammation, evidenced by submesothelial macrophage and T-cell infiltration, which was statistically higher than that observed in the animals submitted only to the PF model, with no associated CKD. This evidence concerns the gene ACTA1 and chronic kidney disease.