Indeed, the canonical NF-κB pathway is one of the most targeted pathways by AEBP1, and the relationship between AEBP1 and the canonical NF-κB pathway is crucial in many types of cancer including, but not limited to, breast cancer, skin cancer, glioblastoma, bladder cancer, gastric cancer, colorectal cancer, ovarian cancer, and leukemia. This evidence concerns the gene NFKB1 and skin neoplasm.