AEBP1 has also been observed to contribute to metastasis and cancer development by modulating various other signaling pathways including PI3K-Akt, sonic hedgehog (Shh), p53 (a tumor suppressor), parthanatos (PARP-1), and PTEN, all of which will be comprehensively discussed in this review. This evidence concerns the gene AEBP1 and neoplasm.