Riku and colleagues [41] demonstrated that TSHZ2, along with CtBP as a corepressor complex, represses the expression of Gli1 and AEBP1 in MCF-7 breast cancer cells, and TSHZ2 knockdown leads to enhanced expression of Gli1 and AEBP1 in primary human mammary epithelial cells (HMECs) and TSHZ2-expressing invasive mammary ductal carcinoma. This evidence concerns the gene GLI1 and breast cancer.