Although a direct relationship between AEBP1 and the canonical NF-κB pathway could not be substantiated in the previous study due to only partial depletion of AEBP1, a recent study by Cheng and colleagues [43] shed light on the effects of AEBP1 on NF-κB signaling by treating glioma cell lines with AEBP1-targeted siRNA. Here, NFKB1 is linked to central nervous system cancer.