SMAD4 and cancer: The χ2 test showed significant differences in the expression of HEATR1 (χ2 = 37.143, P < 0.001), ZNF185 (χ2 = 20.077, P < 0.001), and SMAD4 (χ2 = 23.309, P < 0.001) between the cancer and the normal pancreas.