We found that the chemoresistance pancreatic cancer to gemcitabine was much more significant after HEATR1 knockdown (Figure 1(b)), and the apoptotic percentage decreased (Figure 1(c)) when proliferation increased dramatically (Figure 1(d)) on day 5 after HEATR1 was knockdown. This evidence concerns the gene HEATR1 and familial pancreatic carcinoma.