HEATR1 and familial pancreatic carcinoma: After we examined the HEATR1 mRNA levels in 5 pancreatic cell lines, we firstly knocked down HEATR1 expression in the pancreatic cancer cell line PANC-1 using the RNA interference technique through the lentivirus vector (shHEATR1) and the scrambled sequence as the negative control (shCtrl) (Figure 1(a)).