HEATR1 and cancer: Our team discovered the effect of HEATR1 on the chemosensitivity of gemcitabine and published the original research on Cancer Research in 2016, explaining the possible mechanism in that HEATR1 enhanced the chemosensitivity to gemcitabine by facilitating the interactions between AKT and PP2A and promoting Thr308 dephosphorylation [7].