Although a study showed that patients with one or two DUOX2 mutations turned out to have subclinical or transient CH and that patients with three or more DUOX2 mutations were mostly associated with permanent CH [29], another study showed that disease severity, neurodevelopment, and prognosis were not correlated with DUOX2 mutation types or numbers [30]. The gene discussed is DUOX2; the disease is cyclic hematopoiesis.