ANXA5 and melanoma: As shown in Fig. 1c, the proportion of Annexin V-positive cells indicating the early and late apoptosis was increased 4.6 times in shFyn#1 group and 8.0 times in shFyn#4 group compared with shMock group in melanoma cell Sk-Mel-5 while 2.7 times in shFyn#1 group and 6.5 times in shFyn#4 group in melanoma cell Sk-Mel-28.