BCL2 and melanoma: We further examined the expression of cell cycle- and apoptosis-related genes in Fyn suppressed cells, and the results revealed that Fyn knockdown increased p-P53, P53, P21, and BAX expression and the cleavage of PARP, while it downregulated Bcl-2 (Fig. 1d), suggesting the crucial role of Fyn in melanoma cell apoptosis.