FYN and melanoma: To further verify the specificity of Lj-1-60 targeting Fyn, we explored the effect of this drug on cell viability of Fyn knocked down melanoma cells and the result exhibited that anti-tumor effect of Lj-1-60 was partially reduced in Fyn knocked down cells (Fig. 3c), indicating that Lj-1-60 suppresses the growth of melanoma cells at least partly by targeting Fyn.