In our study, we compared the Fyn expression between melanoma tissues and normal tissues from RNA-seq results of GEO databases (GSE114445 and GSE29359) and also found that Fyn is highly expressed in melanoma, and knocked down of Fyn markedly inhibits melanoma proliferation and induces apoptosis (Fig. 1), indicating the crucial role of Fyn in melanoma. The gene discussed is FYN; the disease is melanoma.