BCL2 and neoplasm: It has been indicated that loss of the miRNA29a level may be involved in up-regulation of BCL2 and MCL1, leading to resistance of cells to apoptosis, and progression of OS, while over-expression of miRNA29a was associated with increased E2F1 and E2F3 expression levels as a tumor suppressor and loss of both BCL2 and MCL1 expression levels [144].