Letiembre et al. explored that SOD1-abundant exosome can upregulate the expression of TLR2 to trigger microglial neurotoxic inflammatory responses [49, 50], while Pinto et al. found that exosome miR-124 could increase the expression of TLR4 to trigger spinal cord astroglial and microglial reaction and enhance spinal motor neuron loss in the ALS [51, 52]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.