In order to establish the contribution of the microenvironment—characterized by increased levels of inflammatory cytokines such as IL-6, a key-player of growth and survival factor for myeloma cells [28,29]—and to induce changes in the HDN phenotype, we evaluated the engagement of the JAK2-STAT3 pathway in autophagy triggering in neutrophils. This evidence concerns the gene JAK2 and plasma cell myeloma.