STAT3 and Miyoshi myopathy: In MM-HDN, phosphorylation of STAT3-S727 was higher than MGUS and healthy HDN (respectively 18.7 ± 3.8 versus 5.3 ± 0.3 versus 3.4 ± 0.5 in MM, p = 0.02, Figure 5A), and was associated with increased protein synthesis of IFNγ, which was higher in MM than MGUS (7.5 ± 0.2 versus 3.8 ± 0.4, p = 0.02) and healthy HDN (7.5 ± 0.2 versus 2.7 ± 0.06, p < 0.0001, Figure 5B).