PIK3C3 and familial pancreatic carcinoma: Other groups reported that the IL-6/JAK2 signaling pathway inhibits autophagy, via p-STAT3, which activates Bcl-2 to regulate the expression of Beclin 1 and VPS34 [46], while in pancreatic cancer, IL-6 induces mitochondrial localization of p-STAT3 at Ser727, upregulating autophagy flux [47].