Cytoplasmic p-STAT3-ser727 constitutively inhibits mitophagy by sequestering GCN2 and its downstream effectors, preserving mitochondria from being degraded when macro-autophagy is triggered by starvation [49], a pathway that could be relevant to preserve neutrophils from apoptosis, thus explaining the long-term survival in culture of MM-HDN. This evidence concerns the gene EIF2AK4 and Miyoshi myopathy.