Conversely, in HDN isolated from three individual healthy donors, incubated for 3 h with completed RPMI or conditioned MM media (obtained from human MM cell lines MM1.s or U266), the percentage of AVO increased (p = 0.001, Figure 5C) and was associated with an increase of STAT3 phosphorylation on S727 (p = 0.01, Figure 5D). Here, STAT3 is linked to Miyoshi myopathy.