CTSB and cancer: In cancer cells, nuclear p-STAT3-S705 can regulate the transcription of several autophagy-related genes such as BCL2 family members (e.g., BECN1, PIK3C3, CTSB, CTSL, PIK3R1, HIF1A, and BNIP3) and microRNAs with targets of autophagy modulators [47].