Highly expressed miR‐21 in intestinal epithelial cells promotes Akt phosphorylation and inhibits PTEN expression, leading to damage to the intestinal mucosa53; miR‐141 inhibits leukocyte migration by downregulating the chemokine CKCL12β, thereby alleviating TNBS‐induced colitis.54 Here, AKT1 is linked to colitis.