We systematically evaluated the immunogenomic landscape of CRC tumours based on gene expression profiles in TCGA database and constructed an immune‐related prognostic signature including SLC10A2, FGF2, CCL28, NDRG1, ESM1, UCN, UTS2 and TRDC. The AUC values for 3‐year and 5‐year OS of this prognostic signature were 79.2% and 76.6%, respectively, indicating moderate predictive accuracy. The gene discussed is ESM1; the disease is colorectal carcinoma.