MAS1L and congestive heart failure: MasR, which serves as a receptor for Angiotensin 1–7, was regulated very similar to AT1R with a significant downregulation in CHF as compared to NF (1.04 ± 0.59 vs. 4.38 ± 1.31 AU, P < 0.001) and without any alteration upon LVAD therapy (see Fig. 6).