MAPK8 and familial dilated cardiomyopathy: Similarly, JNK tended to be upregulated in CHF and after LVAD therapy (see Fig. 10a), even though statistical significance was only met for phosphorylated JNK in DCM patients (2.76 ± 1.52 vs. 1.57 ± 1.21 AU, P = 0.028 by comparing CHF+LVAD vs. CHF; see Fig. 10b).