PIK3R1 and Cowden syndrome 1: Of our 1150 genes JEPETTO analysis for cell cycle related genes (CD22, BTK, PIK3R5, PIK3CG, CD19, PRKCB, INPP5D, NFATC2, PIK3R1, PIK3AP1, FCGR2B and RAC2) showed that their expression was elevated in NS compared to CS.