Pathway analysis using JEPETTO plugin in Cytoscape revealed that cell cycle, DNA replication and repair pathways (MMR, BER, NER), HR, ErbB GnRH, TGF-β, T cell receptor and VEGF signalling pathway as major pathways varying with different constitution for CS and NS analyses and asthma (Table 1). This evidence concerns the gene GNRH1 and asthma.