Of our 1150 genes JEPETTO analysis for cell cycle related genes (CD22, BTK, PIK3R5, PIK3CG, CD19, PRKCB, INPP5D, NFATC2, PIK3R1, PIK3AP1, FCGR2B and RAC2) showed that their expression was elevated in NS compared to CS. This evidence concerns the gene PIK3R5 and Cowden syndrome 1.