Using binary regression including variables reflecting performance status (ECOG) and age, tumor burden (tumor volume, LDH, c-reactive protein levels), tumor entity (OM vs. non-OM), and toxicity, normal levels of LDH (odds ratio (OR) 13.66; p = 0.015) and diagnosis with OM (OR 9.27; p = 0.028) were identified as predictors of achieving a response. The gene discussed is CRP; the disease is ocular melanoma.