Regarding systemic therapies for patients with CCA in the second line, ORRs vary from 8 to 36% for chemotherapy and for FGFR2 inhibition with pemigatinib in selected patients with FGFR2 fusions or rearrangements, respectively (Abou-Alfa et al. 2020; Lamarca et al. 2014). Here, FGFR2 is linked to cholangiocarcinoma.