AMHR2 and polycystic ovary syndrome: To conclude, since neuronal AMH and AMHR2 expression have been associated with embryonic neuronal differentiation in both humans and mice [6, 11] and that PAMH female mice exhibit many PCOS-like traits [43], animal models expressing altered AMH or AMHR2 expression, including genetically manipulated and PAMH mice, together with naturally occurring PCOS-like non-human primates, potentially promise valuable mechanistic insights into this disease.