PFKFB3 and hepatocellular carcinoma: In hepatocellular carcinoma, miR-139-5p inhibits the expression of glycolytic genes, hexokinase 1 (HK1) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) expression by directly targeting the ETS1 transcription factor [34].