For example, through the CRISPR-Cas9 system, the roles of i) LncRoR as activator of MAPK/ERK pathway [127], ii) LncAK023948 as positive regulator in Akt pathway [128] and iii) LncBC200 as promoter of cell growth have been demonstrated in breast cancer [129]. This evidence concerns the gene AKT1 and breast carcinoma.