Ocular involvement specifically uveitis was most commonly identified in NLRP3 low-penetrance variants (n = 12; 63%) in comparison to TNFRSF1A- (n = 14; 24%, p = 0.0169) and MEFV variants (n = 6; 18%, p = 0.0141) (Fig. 6c). The gene discussed is NLRP3; the disease is uveitis.