Headache syndromes were frequently observed among all AID subgroups w/o MS and most commonly found in patients with MEFV- (n = 14; 74%) followed by TNFRSF1A- (n = 5; 63%) and NLRP3 low-penetrance variants (n = 10, 59%). Here, NLRP3 is linked to myeloid sarcoma.