Headache syndromes were frequently observed among all AID subgroups w/o MS and most commonly found in patients with MEFV- (n = 14; 74%) followed by TNFRSF1A- (n = 5; 63%) and NLRP3 low-penetrance variants (n = 10, 59%). The gene discussed is TNFRSF1A; the disease is headache disorder.