Four patients had a concomitant diagnosis of a rheumatic disease (two patients with D12E and N116S variants in the TNFRSF1A gene had rheumatoid arthritis/polyarthritis, one patient with a M694V MEFV variant was diagnosed with systemic lupus erythematosus, and one patient with a compound P369/R408Q MEFV variant was diagnosed with ankylosing spondylitis). Here, TNFRSF1A is linked to rheumatic disorder.