Indeed, SP1 has been reported to play important pathophysiological roles in a variety of neurodegenerative diseases, including Alzheimer's, Huntington, and Parkinson's diseases, and to regulate disease‐related pathogenic genes such as APOE, LRRK2, and P16INK4A.22, 23, 33, 34. This evidence concerns the gene APOE and neurodegenerative disease.