Indeed, SP1 has been reported to play important pathophysiological roles in a variety of neurodegenerative diseases, including Alzheimer's, Huntington, and Parkinson's diseases, and to regulate disease‐related pathogenic genes such as APOE, LRRK2, and P16INK4A.22, 23, 33, 34. The gene discussed is CDKN2A; the disease is neurodegenerative disease.