iPSC-derived neurons (aka iNeurons) are a well-suited system to disclose disease mechanisms and identity and gene expression profiling of patients and control samples allowed to highlight gene processes disrupted in neurodevelopmental disorders (NDDs) [25] including idiopathic autism [26], CHD8 (chromodomain helicase DNA-binding protein 8)-caused autism [27], Rett syndrome [28, 29], Fragile X [30, 31], Prader-Willi/Angelman [32], and Kleefstra [33] syndromes. This evidence concerns the gene CHD8 and atypical Rett syndrome.