CDH8 and Rubinstein-Taybi syndrome: In addition, Rubinstein-Taybi syndrome belongs to the rare monogenic NDDs resulting from defects of the epigenetic machinery [5, 7, 36, 37] including Rett syndrome, CDH8-caused autism, and Kleefstra syndrome, and cross-analysis of the studies performed on transcriptional networks in iNeurons of patients with these NDDs [27, 29, 33] might point to merging dysregulated biological pathways.