PRTN3 and necrotizing vasculitis: This is a proteinase 3 anti-neutrophilic cytoplasmic antibody (PR3-ANCA) positive necrotizing vasculitis characterized by the presence of necrotizing granuloma of the upper and/or lower respiratory tract, necrotizing or granulomatous vasculitis of small- and medium-sized vessels in lungs, upper airways, and other organs and crescentic glomerulonephritis [40].