TRIM35 and infection: In addition, Trim35−/− mice continued to lose body weight until death after infection, whereas all of the Trim35+/+ mice gained body weight at the late stage of infection (Fig. 3I).We also measured virus titers in lung homogenates on day 3 p.i. and found that the viral load was dramatically increased in Trim35−/− mice compared with that in Trim35+/+ mice (Fig. 3J).