CASP1 and Hyperglycemia: IL-1β is produced mainly by monocytes (MO), and hyperglycemia may regulate its production through the assembly of a nucleotide-binding domain and leucine-rich repeat containing family pyrin (NLRP3) of the inflammasome, a cytosolic multi-protein platform where the inactive pro-IL-1β is cleaved into an active form via caspase-1 activity29,30.