SEM3C has been known to transactivate multiple receptor tyrosine kinases and downstreams such as phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, which is causally associated with obesity and glucose metabolism by promoting lipid biosynthesis and glucose uptake and by inhibiting lipolysis59. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.