Oral application of Pg 3 times per week (Mondays, Wednesdays, Fridays) for 22 weeks in mice resulted in glucose intolerance (Fig. 10A), insulin resistance (Fig. 10B) and hyperinsulinemia (Fig. 10C) indicating increased β-cell release of insulin to maintain the normal glucose levels (Fig. 10D)11. Here, JUP is linked to Hyperinsulinemia.