For instance, aggregate-prone proteins—transactive response element DNA/RNA-binding protein of 43 kDa (TDP43) and fused in sarcoma (FUS)—are enriched in inclusion bodies within the neuronal cells of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)55. This evidence concerns the gene TARDBP and frontotemporal dementia.