Examination of one gene set from the schizophrenia database SZDB ([http://www.szdb.org]; genes with scores > =2) revealed that among 279 SZDB genes, 5 (1.8%) and 60 (21.5%) showed reduction (>1.5 fold; p < 0.05) in Top3β-KO mice without and with FC, respectively (Supplementary Fig. 12a; Supplementary Table 4). The gene discussed is TOP3B; the disease is schizophrenia.