TOP3B and schizophrenia: We further identified several schizophrenia-related genes (>20 PubMed citations) that have either significantly reduced Pol II signals (p < 0.05) at both TSS and exons under FC (Fig. 7g), or decreased induction of Pol II signals by FC, in Top3β mutant (Fig. 7h); and confirmed the results using bedgraph analysis (Supplementary Fig. 12c).