TOP3B and Alzheimer disease: Among them are 7 commonly studied learning and memory genes (PubMed citations>20) that have at least 1.5-fold decrease of Pol II signals at both TSS and exons in Top3β-KO mice under FC (Fig. 7e), including those important for AD (App, Mapt, Gsk3b) and dementia (Fus) (Fig. 7f).