In tumor-bearing mice, lncRNA PVT1 regulates the immunosuppressive activity of MDSCs, and lncRNA PVT1 knockdown significantly inhibits the immunosuppressive activity of MDSCs.137 Similarly, lncRNA HOTAIRM1 negatively regulates the immunosuppressive activity of MDSCs by targeting HOXA1 in lung cancer.138 In addition, some ncRNAs regulate the proliferation, differentiation, and recruitment of MDSCs. The gene discussed is PVT1; the disease is lung cancer.