These alterations can subsequently lead to immunosuppression and promote tumor cells to escape destruction by the immune system.45,46 An increasing number of studies have found that ncRNAs can regulate tumor aerobic glycolysis directly (by targeting enzymes related to aerobic glycolysis) or indirectly (by targeting HIF-1α or tricarboxylic acid cycle (TAC)-related enzymes) to help tumors achieve TIE. The gene discussed is HIF1A; the disease is neoplasm.