For example, the IL-6/JAK2/STAT3 signaling pathway can make the TME tend towards immunosuppress by attracting and activating MDSCs, TANs, and Tregs.216 In addition, the IL-6/JAK2/STAT3 signaling pathway has also been found to promote the tumor stem cell-like phenotype and EMT.217–219 In tumors, abnormal expression of ncRNAs can promote TIE by regulating the expression of IL-6 or the molecules involved in the IL-6/JAK2/STAT3 signaling pathway (Table 6). This evidence concerns the gene JAK2 and neoplasm.