lncRNA SNHG14 activates PD-L1 expression at the transcriptional level via ZEB1 and miR-5590-3p, thus promoting immune escape of diffuse large B cell lymphoma.172 circRNA CDR1-AS positively regulates PD-L1 levels and leads to poor prognosis in patients with colorectal cancer.173 lncRNA NKX2-1-AS1 inhibits PD-L1 expression in tumor cells at the transcriptional level, thus inhibiting immunosuppression and preventing TIE in lung carcinoma cells.174. The gene discussed is CD274; the disease is colorectal cancer.