For example, the miR-17-92 cluster,77 miR-22,78 miR-33a,79 and circRNA EPHB480 have been reported to downregulate HIF-1α expression in different types of tumors, while miR-21 can promote the expression of HIF-1α in prostate cancer cells; lncRNA SNHG1,81 lncRNA 0015282 and circRNA PIP5KA83 function as molecular sponges for miR-18a, miR-138 and miR-600, respectively, to promote HIF-1α expression in different tumors. This evidence concerns the gene HIF1A and Familial prostate cancer.