TIM-3 is an immune checkpoint molecule expressed on the surface of DCs, NK cells, Tregs, macrophages, and IFN-γ-producing T cells.182 TIM-3 inhibits the function of type 1T helper cells and the secretion of several immune factors, such as IFN-γ and TNF.182 In addition, as an immune checkpoint molecule, TIM-3 can also inhibit antitumor immunity by depleting tumor-infiltrating T cells.183 Therefore, in tumors, regulating the expression of TIM-3 is also one of the mechanisms to achieve TIE, and ncRNAs are significant players in this regulation. Here, HAVCR2 is linked to neoplasm.