For example, miR-206 inhibits PGE2-induced proliferation and metastasis of colon cancer cells by targeting the transmembrane 4 L six family member 1 (TM4SF1) protein,88 while miR-128,89 miR-146a,90 miR-101,91 and miR-14392 can inhibit tumor progression by decreasing COX-2. Here, TM4SF1 is linked to malignant colon neoplasm.