In mice with glioma, miR-138 significantly reduces the expression of CTLA-4 and PD-1 on the surface of tumor-infiltrating T cells.151 In mice with melanoma, miR-155 inhibits CTLA-4 expression on the surface of tumor-infiltrating T cells and promotes the host antitumor immune response.152. Here, CTLA4 is linked to glioma.