miR-34a promotes the proliferation of MDSCs by inhibiting their apoptosis,139 whereas miR-9 regulates the differentiation and function of MDSCs by targeting runt-related transcription factor 1 (Runx1).140 Conversely, the lack of miR-155 in B16-F10 melanoma and Lewis lung carcinoma cell lines leads to the recruitment of MDSCs in the TME and subsequently enhances immunosuppression.141. This evidence concerns the gene RUNX1 and Carcinoma, Lewis Lung.