MYD88 and Alzheimer disease: Moreover, alleviation or complete ablation of MyD88 signaling has been demonstrated as beneficial in several central nervous system pathologies, i.a., animal experimental autoimmune encephalomyelitis model [77], neuropathic pain [78], traumatic brain injury [79, 80], epilepsy [81, 82], Alzheimer's disease [83], hypoxic neonatal brain injury in LPS-sensitized mice [84], subarachnoid hemorrhage [85], as well as ischemic stroke [86, 87].