MYD88 and obesity due to melanocortin 4 receptor deficiency: A recent study reported that interaction between circulating saturated free fatty acids (sFFAs) and TLR4 was involved in the hypothalamic control of energy homeostasis and that mice bearing neuron-specific deletion of the Myd88 gene were protected against HFD-induced obesity through the alleviation of hypothalamic inflammation and leptin resistance [21].