PSEN1 and Alzheimer disease: In addition to rTg4510 mice, the accumulation of αSyn has also been found in DLB-AD transgenic mice, which express human mutant APP, PSEN1, tau (P301L), and αSyn (A53T) [5], and in bigenic mice that express wild-type human αSyn and mutant tau (P301L) [15].