Besides, HIF-2α accumulation under hypoxic microenvironment could promote EGFR mRNA translation and diminish the necessity for EGFR mutations [38], the mutual promotion of EGFR and HIF-2α - p300 - ZNF395 pathway turned out to be significant driver of tumorigenic progression of ccRCC. This evidence concerns the gene EP300 and nonpapillary renal cell carcinoma.