An open-label phase II study aims to assess the safety and efficacy of SHR-1210 (an anti-PD-1 antibody) plus apatinib mesylate (an anti-vascular endothelial growth factor (VEGF) receptor-2 inhibitor) versus pemetrexed (an antimetabolite) and carboplatin (an alkylating agent) in adult patients with KRAS+ stage IV NSCLC (NCT03777124). Here, KRAS is linked to non-small cell lung carcinoma.