HACD1 and hereditary disease: SINE insertions cause several genetic diseases; examples include: (i) a SINE in the hypocretin (orexin) receptor 2 gene causing canine narcolepsy [39]; (ii) a SINE in the protein tyrosine phosphatase-like, member A (PTPLA) resulting in gene centronuclear myopathy [55]; and (iii) an intronic SINE insertion in the FAM161A gene causing progressive retinal atrophy (PRA) in dogs [41].