To better understand the potential role of Integrins in RB and resistance development, the mRNA expression levels of the Integrin receptor subunits α4 (ITGA4), α5 (ITGA5), and β1 (ITGB1) were analyzed in both WERI cell lines via RT-qPCR (Figure 1D). This evidence concerns the gene ITGA5 and retinoblastoma.